The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy

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• 作者：Anne C. Brun^a ; ^{acbrun@gmail.com} ; Ketil St&#248 ; rdal^b ; ^{ketil.stoerdal@c2i.net} ; Groa B. Johannesdottir^c ; ^groaj@fsa.is ; Beint S. Bentsen^d ; ^{Beint.Sigmund.Bentsen@oslo-universitetssykehus.no} ; Asle W. Medhus^d ; ^{a.w.medhus@medisin.uio.no}
• 关键词：Cerebral palsy ; Gastrostomy ; Gastric emptying ; Protein ; Gastrointestinal symptoms
• 刊名：Clinical Nutrition
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：31
• 期：1
• 页码：108-112
• 全文大小：262 K

文摘

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Summary

Background & aim

Dysmotility, nausea and vomiting are common among children with cerebral palsy. This study aimed to evaluate influence of protein composition on rate of gastric emptying and study the relation between gastric emptying and postprandial gastrointestinal symptoms.

Methods

15 children with cerebral palsy, using gastrostomy, received four liquid test meals on separate days in random order. The meals contained a standard carbohydrate and fat base plus one of four protein modules (100 % casein (A), hydrolysed whey (B), amino acids (C) and 40 % casein/60 % whey (D)) with a total energy of 1?kcal/ml. The ¹³C octanoic acid breath test was applied to assess gastric emptying.

Results

When comparing half emptying time (T_1/2) of the fast emptying meals (meal B, C and D) with the slowest emptying meal (meal A), more rapid emptying was demonstrated for meal D (p?<?0.001). For meal D, emptying was significantly faster in children with postprandial symptoms than in those without (p?<?0.01).

Conclusion

In children with cerebral palsy using gastrostomy, gastric emptying is influenced by type of protein in the meal. The present results also suggest that there is a relation between rapid gastric emptying and postprandial gastrointestinal symptoms.

ClinicalTrials.gov

UUSKBK 28200706.