Combining sequence and Gene Ontology for protein module detection in the Weighted Network

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• 作者：Yang Yu^a ; ^c ; ^{yuyangsd1204@126.com} ; Jie Liu^a ; Nuan Feng^b ; ^{279901222@qq.com} ; Bo Song^a ; Zeyu Zheng^c
• 关键词：Protein complex ; Protein interaction ; Gene Ontology ; The Weighted Network
• 刊名：Journal of Theoretical Biology
• 出版年：2017
• 出版时间：7 January 2017
• 年：2017
• 卷：412
• 期：Complete
• 页码：107-112
• 全文大小：883 K
• 卷排序：412

文摘

Sequence and gene ontology are combined for protein complex detection. The weighted graphs based on gene ontology and PPI network are constructed. In the clustering part, density, diameter and the included angle cosine are employed for locating candidate complexes. The experimental results show that the proposed method can generally perform better than five useful methods in forms of recall and f-measure.