IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy
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- 作者：Keyla Santos Guedes de Sá ; a ; Bá ; rbara Brasil Santanaa ; Tuane Carolina de Souza Ferreiraa ; Rita Catarina Medeiros Sousab ; Cezar Augusto Muniz Caldasb ; Vâ ; nia Nakauth Azevedoa ; Rosimar Neris Martins Feitosaa ; Luiz Fernando Almeida Machadoa ; Marluí ; sa de Oliveira Guimarã ; es Ishaka ; Ricardo Ishaka ; Antonio Carlos Rosá ; rio Vallinotoa ; vallinoto@ufpa.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：HAA ; artropatia associada ao HTLV ; HAM/TSP ; Paraparesia Espá ; stica Tropical/Mielopatia Associada ao HTLV-1 ; HTLV-1 ; human T-lymphotropic virus 1 ; HTLV-2 ; human T-lymphotropic virus 2 ; ISGs ; interferon stimulated genes ; SNPs ; polimorfismos de nucleotí ; deo ú ; nico
- 刊名：Cytokine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：79-87
- 全文大小：1087 K
文摘
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Association between HTLV-associated arthropathy (HAA) and IL28B gene was investigated.
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Individuals with HAA exhibited low IL-6 and high IL-10 levels.
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Genotype TT might be a risk factor for proviral load and CD8+ T cell count.
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Genotypes CC and TT seem to be associated with increased TNF-β and IFN-γ levels.