Aβ1–42 resulted in a significant decline of spatial learning and memory of rats.
Exendin-4 protected against the Aβ1–42-induced impairment of spatial memory.
Exendin-4 decreased the level of Bax and caspase-3 in Aβ1–42-induced rats.
Exendin-4 increased the level of Bcl2 in Aβ1–42-induced Alzheimer-like symptoms rat.