Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid-β peptide-induced impairment of spatial learning and memory in rats
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- 作者：Xiao-Tao Jiaa ; Ye-Tiana ; Yuan-Lic ; Ge-juan Zhanga ; Zhi-qin Liua ; Zheng-Li Dia ; Xiao-Ping Yingb ; Yan Fangb ; Er-fei Songd ; Jin-shun Qic ; jinshunqi2009@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan-Fang Panb ; panyanfang2000@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Exendin-4 ; Amyloid-β peptide ; Spatial learning and memory ; Bcl2/Bax ; Caspase-3
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：72-79
- 全文大小：795 K
文摘
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Aβ1–42 resulted in a significant decline of spatial learning and memory of rats.
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Exendin-4 protected against the Aβ1–42-induced impairment of spatial memory.
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Exendin-4 decreased the level of Bax and caspase-3 in Aβ1–42-induced rats.
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Exendin-4 increased the level of Bcl2 in Aβ1–42-induced Alzheimer-like symptoms rat.