Preventive effect of genetic knockdown and pharmacological blockade of CysLT₁R on lipopolysaccharide (LPS)-induced memory deficit and neurotoxicity in vivo

详细信息    查看全文

• 作者：Fang Chen^a ; ¹ ; Arijit Ghosh^a ; ¹ ; ² ; Feng Wu^b ; Susu Tang^a ; Mei Hu^a ; Hongbin Sun^a ; Lingyi Kong^a ; Hao Hong^a ; ^{honghao@cpu.edu.cn}
• 关键词：Alzheimer&rsquo ; s disease ; Bcl-2/Bax ; Caspase-3 ; CysLT1R ; IL-1β ; Microglia ; NF-κB p65 ; Pranlukast ; shRNA ; TNF-α
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：255-269
• 全文大小：4036 K
• 卷排序：60

文摘

LPS-induced memory deficit in mice is accompanied by hippocampal CysLT1R upregulation. shRNA-mediated knockdown of CysLT1R prevents LPS-induced memory impairment. Pranlukast, a CysLT1R antagonist, prevents neurotoxicity in mice induced by LPS.