Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation

详细信息    查看全文

• 作者：Pamela V. Martino Adami^a ; Pablo Galeano^a ; ^b ; Marina L. Wallinger^c ; Celia Quijano^d ; Alejandro Rabossi^e ; Eleonora S. Pagano^c ; Natividad Olivar^f ; Carlos Reyes Toso^c ; Daniel Cardinali^c ; Luis I. Brusco^f ; Sonia Do Carmo^g ; Rafael Radi^d ; Goar Gevorkian^h ; Eduardo M. Castañ ; o^a ; A. Claudio Cuello^g ; Laura Morelli^a ; ^{lmorelli@leloir.org.ar}
• 关键词：3-TyrNO2 ; 3-nitrotyrosine ; AβN3(pE) ; pyroglutamate-Aβ ; iAβ ; intraneuronal Aβ ; BBB ; blood-brain barrier ; BHI ; Bioenergetic Health Index ; CRTC ; CREB-regulated transcription coactivator ; IDE ; insulin degrading enzyme ; IR ; insulin resistance ; MetS ; metabolic syndrome ; OCR ; oxygen consumption rate ; PGC-1α ; PPARɣ coactivator 1α ; SD ; standard diet ; Sirt1 ; Sirtuin 1 ; SO ; stratum oriens ; SOD ; superoxide dismutase ; SP ; stratum pyramidale ; SRC ; spare respiratory capacity ; T2DM ; type 2 diabetes mellitus ; WA
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：731-743
• 全文大小：2185 K
• 卷排序：1863

文摘

High fat/high sugar diet worsens cognition in absence of neuroinflammation. Energy-dense diet downregulates hippocampal Sirt1 transcription. Impaired Sirt1-related neuroprotective pathways aggravate hippocampal bioenergetics. Energy-dense diet increases Aβ levels and generates highly neurotoxic AβN3(pE).