Activation of GPR30 stimulates GTP-binding of Gαi1 protein to sustain activation of Erk1/2 in inhibition of prostate cancer cell growth and modulates metastatic properties
GPR30 activation by G-1 activates Gαi1 to sustain Erk1/2 activation in PCa cells. Stimulations of AC-cAMP-PKA signaling block the G-1-induced cell growth inhibition. Molecular consequences of GPR30 activation by G-1 in PCa cells are demonstrated. Roles of GPR30 in controlling metastatic properties of PCa cells are revealed.