Supramolecular aggregates of oligosaccharides with co-solvents in ternary systems for the solubilizing approach of triamcinolone
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- 作者：Arthur S.A. de Medeirosa ; arthurmedeiros@ymail.com" class="auth_mail" title="E-mail the corresponding author ; Ariana Zoppib ; ariana@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding author ; Euzé ; bio G. Barbosaa ; euzebiogb@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jonas I.N. Oliveirac ; jonasivan@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Matheus F. Fernandes-Pedrosaa ; mpedrosa@ufrnet.br" class="auth_mail" title="E-mail the corresponding author ; Marcela R. Longhib ; mrlcor@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding author ; Arnó ; bio A. da Silva-Jú ; niora ; arnobiosilva@gmail.com" class="auth_mail" title="E-mail the corresponding author ; arnobiosilva@ufrnet.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Triamcinolone (PubChem CID ; 31307) ; Beta-cyclodextrin (PubChem CID ; 444041) ; Hydroxipropil-beta-cyclodextrin (PubChem CID ; 14049689) ; Methyl-beta-cyclodextrin (PubChem CID ; 162771) ; Triethanolamine (PubChem CID ; 7618) ; 1-Methyl-2-pyrrolidinone (PubChem CID ; 13387)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：1040-1051
- 全文大小：2575 K
文摘
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Triamcinolone interactions with three oligosaccharides and two co-solvents were investigated.
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The supramolecular aggregate structure was assessed in a wide experimental approach.
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Incredibly stable complexes with cyclodextrins were formed with high drug solubilization.
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Ternary associations stabilized the formation of unimodal complexes.