DSP4 did not modify sensorial pain responses in neuropathic animals.
DSP4 accentuated neuropathic escape behavior in the place escape/avoidance test.
DSP4 enhanced ERK activation in the anterior cingulate cortex in neuropathic animals.
Desipramine attenuated the place escape/avoidance behavior in neuropathic animals.
Desipramine did not modify p-ERK expression in the anterior cingulate cortex.