More, More, More: Downregulation of a MK5-FoxO3a-mir34b/c Pathway Further Increases c-Myc Levels in Colorectal Cancer

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• 作者：Kevin Myant¹ ; Owen J. Sansom¹ ; ^{o.sansom@beatson.gla.ac.uk}
• 刊名：Molecular Cell
• 出版年：2011
• 出版时间：18 February 2011
• 年：2011
• 卷：41
• 期：4
• 页码：369-370
• 全文大小：142 K

文摘

The c-Myc transcription factor has been shown to be central for colorectal carcinogenesis. In this issue of Molecular Cell, Kress and colleagues (Kress et al., 2011) identify an exciting new pathway that downregulates c-Myc translation which is lost in aggressive colorectal cancer.