Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer
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- 作者：Youyi Daia ; 1 ; Huaxin Duanb ; c ; 1 ; Chaojun Duand ; Rongrong Zhoua ; Yuxiang Hea ; Qingsong Tua ; Liangfang Shena ; 3153559525@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transcription factor 21 (TCF21) ; DNA methylation ; Colorectal cancer ; Cell proliferation ; Cell migration ; Cell invasion
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：469
- 期：3
- 页码：430-436
- 全文大小：1299 K
文摘
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TCF21 was frequently silenced by promoter DNA methylation in CRC cells.
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TCF21 was frequently methylated in primary CRC and significantly correlated with metastasis.
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Restoration of TCF21 promotes cell apoptosis of CRC cells.
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Restoration of TCF21 inhibits cell invasion and migration of CRC cells.