Anal incontinence and vesico-sphincter events in systemic sclerosis: An epidemiologic bicentric cohort study

详细信息    查看全文

• 作者：Mickaë ; l Martin^a ; ^{mickael.martin@chru-strasbourg.fr" class="auth_mail" title="E-mail the corresponding author} ; Nadine Meaux-Ruault^a ; Nadine Magy-Bertrand^a ; Guillaume Beraud^b ; Bernard Parratte^c ; Pascal Roblot^b
• 关键词：AI ; anal incontinence ; HADS ; hospital anxiety and depression scale ; QoL ; quality of life ; SF-36 ; short form health survey 36v2 ; SSc ; systemic sclerosis ; UDI-6 ; urogenital distress inventory ; UI ; urinary incontinence ; VAS ; visual analogic scales ; VSE ; vesico-sphincter events
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：46
• 期：1
• 页码：124-132
• 全文大小：539 K

文摘

To estimate the frequency and severity of anal incontinence and vesico-sphincter events, associated factors, and impact on the quality of life of patients with systemic sclerosis.

Methods

Questionnaires assessing anal incontinence (Miller score), vesico-sphincter events (Urogenital Distress Inventory) and quality of life [Short Form Health Survey 36v2 (SF-36), and Hospital Anxiety and Depression Scale] were mailed to 139 patients with systemic sclerosis at the university hospitals of Besançon and Poitiers, France. Clinical data were collected from the medical records to identify risk factors.

Results

Among the 121 (87%) responders, severe vesico-sphincter events or severe anal incontinence occurred in 3.4% and 12.4% of cases, respectively. Frequent urination (66.3%) and anal incontinence to gas (50.4%) were the most frequent symptoms. Anal incontinence was associated positively with vesico-sphincter events, unrelated to obstetrical factors. No correlations were seen with age, sex, or systemic sclerosis characteristics. In multivariate analysis, moderate or severe vesico-sphincter events was associated with higher anxiety and depression scores and lower SF-36 scores; the same results were observed for anal incontinence, but did not reach significance.

Conclusion

Vesico-sphincter events and anal incontinence are common in systemic sclerosis, and sometimes severe, with a potential negative impact in quality of life. These results will be confirmed by a case-control study with dynamic and manometric assessment, and could legitimate a systematic screening to ensure early therapy and multidisciplinary individual management.