Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception
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- 作者：Iulia I. Nitaa ; 1 ; Yaki Caspib ; c ; 1 ; Sagi Gudesb ; c ; Dimitri Fishmana ; Shaya Levb ; c ; Michal Hersfinkela ; Israel Seklera ; 2 ; israel.sekler@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Alexander M. Binshtokb ; c ; 2 ; alexander.binshtok@ekmd.huji.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-APB ; 2-aminoethoxydiphenyl borate ; AAV ; adeno-associated virus ; [Ca2 ; +]C ; cytosolic Ca2 ; + ; [Ca2 ; +]M ; mitochondrial Ca2 ; + ; ; CCCP ; carbonyl cyanide m-chlorophenyl hydrazone ; CGP37157 ; 7-chloro-5-(2-chlorophenyl)-1 ; 5-dihydro-4 ; 1-benzothiazepin-2(3H)-one ; DRG ; dorsal root ganglion ; IP3R ; inositol 1 ; 4 ; 5-trisphosphate receptors ; FCCP ; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone ; MCU ; mitochondrial Ca2 ; + uniporter ; NCLX ; mitochondrial Na+/Ca2 ; + exchanger ; R
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：1863
- 期：12
- 页码：2868-2880
- 全文大小：1907 K
文摘
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In nociceptors TRPV1-mediated Na+ and Ca2 + fluxes propagate into mitochondria.
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Mitochondrial MCU and NCLX propagate TRPV1 but not RyR-mediated Ca2 + transients.
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Knockdown of the NCLX attenuates TRPV1-induced neuronal firing and cell death.
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TRPV1/MCU/NCLX interactions are required for Ca2 +-dependent regulation of TRPV1.
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Cross-talk between mitochondrial MCU/NCLX and TRPV1 is essential for nociception.