Cartilage and meniscus assessment using T1rho and T2 measurements in healthy subjects and patients with osteoarthritis

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• 作者：Z.A. Zarins ; R.I. Bolbos ; J.B. Pialat ; T.M. Link ; X. Li ; R.B. Souza ; S. Majumdar
• 关键词：Osteoarthritis ; Cartilage ; Meniscus ; T_1&#x3c1 ; ; T₂ ; Magnetic Resonance Imaging
• 刊名：Osteoarthritis and Cartilage
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：18
• 期：11
• 页码：1408-1416
• 全文大小：470 K

文摘

Summary

Objective

The purpose of this study was to evaluate meniscal degeneration in healthy subjects and subjects with osteoarthritis (OA) using T_1ρ and T₂ measurements and to examine the interrelationship between cartilage and meniscus abnormalities.

Methods

Quantitative assessment of cartilage and meniscus was performed using 3T Magnetic Resonance Imaging (MRI) with a T_1ρ and T₂ mapping technique in 19 controls and 44 OA patients. A sagittal T₂-weighted fast spin echo (FSE) fat-saturated image was acquired for cartilage and meniscal Whole-Organ Magnetic Resonance Imaging Score (WORMS) assessment. Western Ontario and McMasters Universities Arthritis Index (WOMAC) scores were obtained to assess clinical symptoms.

Results

The posterior horn of the medial meniscus (PHMED) had the highest incidence of degeneration. Stratifying subjects on the basis of PHMED grade revealed that the T_1ρ and the T₂ measurements of the PHMED and the medial tibial (MT) cartilage were higher in subjects having a meniscal tear (meniscal grade 2–4) compared to subjects with a meniscal grade of 0 or 1 (P < 0.05). While not statistically significant, there was a trend for T_1ρ and T₂ being higher in PHMED grade 1 compared to grade 0 (P = 0.094, P = 0.073 respectively). WOMAC scores had a stronger correlation with meniscus relaxation measures than cartilage measures.

Conclusions

Magnetic Resonance (MR) T_1ρ and T₂ measurements provide a non-invasive means of detecting and quantifying the severity of meniscal degeneration. Meniscal damage has been implicated in OA progression and is correlated with cartilage degeneration. Early detection of meniscal damage represented by elevations in meniscal relaxation measures may identify subjects at increased risk for OA.