Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
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- 作者：Sumedha Baggaa ; Siddhartha Rawata ; 1 ; Marcia Ajenjob ; c ; Michael J. Bouchardc ; michael.bouchard@drexelmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HBV ; Hepatitis B virus ; HCC ; Hepatocellular carcinoma ; HBx ; HBV X protein ; cccDNA ; Covalently closed circular DNA ; ORF ; Open reading frame ; mTORC1 ; Mammalian target of rapamycin (mTOR) complex 1 ; TSC2 ; Tuberous-sclerosis complex-2 ; AMPK ; AMP-activated protein kinase ; S6K ; p70 S6 Kinase ; 4EBP1 ; Eukaryotic translation initiation factor 4E binding protein 1 ; AMPKK ; AMPK-kinase ; LKB1 ; Liver kinase B1 ; PKCζ ; Protein kinase C ζ ; ACC ; Acetyl-CoA Carboxylase ; ITS ; Insulin-transferrin-selenium ; EGF ; Epid
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：9-22
- 全文大小：1543 K
文摘
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Analysis of HBx modulation of AMPK/mTORC1 signaling in primary hepatocytes.
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HBx activation of AMPK stimulates HBV replication.
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HBx activation of mTORC1 inhibits HBV replication.
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HBx simultaneously activates pathways that stimulate and repress HBV replication.
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HBx acts as a rheostat that controls the level of HBV replication.