Establishment of a highly metastatic buccal squamous cell carcinoma cell line from a Sprague-Dawley Rat
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- 作者：Xing Qina ; b ; 1 ; xingzaing@163.com" class="auth_mail" title="E-mail the corresponding author ; Ming Yana ; 1 ; yanming8012@126.com" class="auth_mail" title="E-mail the corresponding author ; Jianjun Zhanga ; zjjshuobo@163.com" class="auth_mail" title="E-mail the corresponding author ; Qin Xua ; b ; xuqin_2004@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Zhongjing Lva ; yjlzj123@126.com" class="auth_mail" title="E-mail the corresponding author ; Wantao Chena ; b ; chenwantao196323@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：SCC ; squamous cell carcinoma ; 4NQO ; 4-nitroquinoline-1-oxide ; OSCC ; oral squamous cell carcinoma ; PBS ; phosphate-buffer saline ; FBS ; fetal bovine serum ; PDT ; population doubling time ; PI ; propidium iodide ; EMT ; epithelial-mesenchymal transition
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：1-9
- 全文大小：5084 K
文摘
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We established a model of buccal squamous cell carcinoma in Sprague-Dawley Rat by 4-nitroquinoline-1-oxide added drinking water.
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A cell line titled “Rca-B” was isolated from the tumor tissue successfully.
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The in vivo and in vitro biological characteristics of Rca-B were well investigated and confirmed, which suggested a highly metastatic malignant feature of Rca-B.
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The malignant behaviors of Rca-B would be valuable for investigating the molecular mechanisms of buccal SCC progression.