The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation
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- 作者：Karine Jacquet1 ; 2 ; Amé ; lie Fradet-Turcotte1 ; 2 ; 3 ; Nikita Avvakumov1 ; 2 ; Jean-Philippe Lambert3 ; Cé ; line Roques1 ; 2 ; Raj K. Pandita4 ; Eric Paquet1 ; 2 ; Pauline Herst1 ; 2 ; Anne-Claude Gingras3 ; 5 ; Tej K. Pandita4 ; Gaë ; lle Legube6 ; Yannick Doyon2 ; Daniel Durocher3 ; 5 ; Jacques Cô ; té ; 1 ; 2 ; jacques.cote@crhdq.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：TIP60 ; MBTD1 ; NuA4 ; 53BP1 ; histone methylation ; acetylation ; ubiquitylation ; H4K20 ; H2AK15 ; homologous recombination
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：62
- 期：3
- 页码：409-421
- 全文大小：3852 K
文摘
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We identify MBTD1 as a stable subunit of the TIP60/NuA4 complex
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MBTD1 as part of TIP60 regulates transcription and repair of DNA breaks
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MBTD1 competes with 53BP1 for binding to the H4K20me mark
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TIP60 acetylates H2AK15 and blocks its ubiquitylation by RNF168