A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
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- 作者：Pedro P. Rocha1 ; pereip02@nyumc.org" class="auth_mail" title="E-mail the corresponding author ; Ramya Raviram1 ; 2 ; Yi Fu1 ; JungHyun Kim1 ; Vincent M. Luo1 ; Arafat Aljoufi1 ; Emily Swanzey3 ; Alessandra Pasquarella4 ; Alessia Balestrini5 ; Emily R. Miraldi7 ; Richard Bonneau2 ; 6 ; 7 ; John Petrini5 ; Gunnar Schotta4 ; Jane A. Skok1 ; jane.skok@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：48-55
- 全文大小：1933 K
文摘
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53BP1 is essential for preferential targeting of the upstream switch region
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53BP1’s absence results in increased interaction frequency between switch regions
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Alterations in switch region targeting and locus architecture impact CSR
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53BP1’s action is independent of its role in the double-strand break repair pathway