53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms
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- 作者：Raquel Cuella-Martin1 ; Catarina Oliveira1 ; Helen E. Lockstone2 ; Suzanne Snellenberg1 ; Natalia Grolmusova1 ; J. Ross Chapman1 ; 3 ; rchapman@well.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：64
- 期：1
- 页码：51-64
- 全文大小：3770 K
文摘
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53BP1 enhances genome-wide p53-dependent transcriptional responses
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53BP1’s DNA repair and p53-regulatory roles are distinct and separable
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Regulation requires 53BP1 oligomerization and BRCT domain interactions with p53 and USP28
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53BP1-USP28 complexes function to stimulate p53 DNA-binding activity