Exopolysaccharide from Trichoderma pseudokoningii induces the apoptosis of MCF-7 cells through an intrinsic mitochondrial pathway
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- 作者：Guodong Wanga ; b ; 1 ; Chunyan Liub ; 1 ; Jun Liua ; Bo Liua ; Ping Lib ; Guozheng Qinb ; Yanghui Xub ; Ke Chena ; Huixia Liua ; lhx900@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Kaoshan Chenb ; c ; ksc313@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dimethyl sulfoxide (PubChem CID ; 679) ; Propidium iodide (PubChem CID ; 104981) ; Hoechst 33258 (PubChem CID ; 5491656) ; JC-1 (PubChem CID ; 5492929) ; DCFH-DA (PubChem CID ; 77718)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：1065-1073
- 全文大小：2803 K
文摘
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Exopolysaccharide (EPS) could inhibit the proliferation of MCF-7 cells and induce lactic dehydrogenase release in vivo.
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EPS induces apoptosis and arrests MCF-7 cells in S phase of the cell cycle.
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EPS may trigger apoptosis through an intrinsic mitochondrial apoptotic pathway.