The human colonic thiamine pyrophosphate transporter (hTPPT) is a glycoprotein and N-linked glycosylation is important for its function
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- 作者：Svetlana M. Nabokina ; Veedamali S. Subramanian ; Hamid M. Said ; hmsaid@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thiamine pyrophosphate ; Glycosylation ; Transport ; Uptake ; Mutation
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1858
- 期：4
- 页码：866-871
- 全文大小：820 K
文摘
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hTPPT is the glycosylated protein.
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N-glycosylation occurs at Asn69, Asn155, Asn197, Asn393, and Asn416.
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Glycosylation at Asn69, Asn155, and Asn393 is important for hTPPT functionality.
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This study provides a support for a 10 TMD topology for the hTPPT.