Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1
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- 作者：Daniel Pastor-Floresa ; Jö ; rg O. Schulzea ; Anna Bahí ; b ; c ; Evelyn Sü ; ß ; a ; Antonio Casamayorb ; c ; antonio.casamayor@uab.es" class="auth_mail" title="E-mail the corresponding author ; Ricardo M. Biondia ; biondi@med.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Budding yeast ; C. albicans ; Pkh ; PDK1 ; Cell wall integrity ; Allostery ; Sphingosine ; PHS ; DHS ; PI(3 ; 4)P2 ; PI(4 ; 5)P2 ; PI(3 ; 4 ; 5)P3 ; PIP3 ; Sulfatide ; Phosphatidic acid ; Phosphatidylserine ; Phosphatidylethanolamine ; Phosphatidylcholine
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1861
- 期：3
- 页码：249-259
- 全文大小：1307 K
文摘
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CaPkh2, the Candida ortholog of PDK1, requires a C-terminal region for activity
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CaPkh2 has a putative PH domain and binds to structural and signaling lipids
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CaPkh2 binds to sulfatide, but it does not affect kinase activity
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Phospholipds inhibit CaPkh2 in vitro activity while DHS reverses inhibition
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Pkh kinases and PDK1 have similarities and differences in their mechanisms of regulation by lipids