Effect of two polymorphisms of the resistin gene (rs10401670 and rs1862513) on resistin levels and biochemical parameters in morbidly obese patients 1 year after a biliopancreatic diversion surgery

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• 作者：Daniel Antonio de Luis ; ^{dadluis@yahoo.es" class="auth_mail" title="E-mail the corresponding author} ; Olatz Izaola ; David Primo ; Rocio Aller ; David Pacheco
• 关键词：Biliopancreatic diversion ; Resistin gene ; SNPs ; Morbid obesity ; Surgery
• 刊名：Clinical Nutrition
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：6
• 页码：1517-1521
• 全文大小：234 K

文摘

Two single nucleotide polymorphisms (SNPs) of the resistin gene RETN have been described: rs10401670 and rs1862513. The objective of this study was to investigate the effect of these SNPs on changes in serum resistin levels, biochemical parameters and weight after biliopancreatic diversion surgery in morbidly obese patients without diabetes mellitus.

Methods

A sample of 155 patients with morbid obesity without diabetes mellitus was enrolled. Anthropometric and biochemical evaluations were realized at the basal visit and at 12 months. The percentage of subjects with hypertension and hyperlipidemia was also reported.

Results

Initial percentage excess weight loss, body mass index, weight, waist circumference, fat mass, blood pressure, low-density lipoprotein cholesterol, total cholesterol, triglycerides levels, insulin and the homeostasis model assessment for insulin sensitivity (HOMA-IR) improve after 12 months. No differences in these improvements were detected between the two genotypes (wild vs mutant group) in each SNP analysis. Resistin levels only changed after surgery in wild genotypes of both SNPs (rs1862513 and rs10401670). The improvement in insulin levels was lower in the mutant group of rs1862513 (−3.4 ± 0.4 UI/dl vs −2.3 ± 0.2 UI/dl; P < 0.05) and rs1040167 (−3.3 ± 0.2 UI/dl vs −1.9 ± 0.3 UI/dl; P < 0.05). The decrease of HOMA-IR was lower in mutant group of rs1862513 (−1.4 ± 0.1 units vs −0.9 ± 0.3 units; P < 0.05) and rs10401670 (−1.2 ± 0.2 units vs −0.9 ± 0.3 units; P < 0.05).

Conclusions

The main result of this study was that the mutant genotype of two SNPs of the RETN gene (rs1862513 and rs10401670) was associated with a lack of change in resistin secondary to biliopancreatic diversion. The improvement in insulin levels and HOMA-IR was also lower in these patients.