PET Imaging of Hypoxia

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• 作者：Suzanne E. Lapi ; PhD ; ^{lapis@mir.wustl.edu} ; Thomas F. Voller ; BSc ; Michael J. Welch ; PhD
• 关键词：Positron emission tomography (PET) ; Hypoxia ; 18F-MISO ; 64Cu-ATSM ; Nitroimidazole
• 刊名：PET Clinics
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：4
• 期：1
• 页码：39-47
• 全文大小：625 K

文摘

Hypoxia imaging has applications in functional recovery in ischemic events such as stroke and myocardial ischemia, but especially in tumors in which hypoxia can be predictive of treatment response and overall prognosis. Recently, there has been development of imaging agents using PET for non-invasive imaging of hypoxia. Many of these PET agents have come to the forefront of hypoxia imaging. Halogenated PET nitroimidazole imaging agents labeled with ¹⁸F (t_1/2 = 110 m) and ¹²⁴I (t_1/2 = 110 m) have been under investigation for the last 25 years, with radiometal agents (⁶⁴Cu-ATSM) being developed more recently. This article focuses on these PET imaging agents for hypoxia.