Polylactides—Methods of synthesis and characterization

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• 作者：Julia Pretula ; Stanislaw Slomkowski ; ^{staslomk@cbmm.lodz.pl} ; Stanislaw Penczek
• 关键词：L-Lactic acid (PubChem CID ; 107689) ; D-Lactic acid (PubChem CID ; 61503) ; L-Lactide (PubChem CID ; 107983) ; D-Lactide (PubChem CID ; 5325924) ; meso-Lactide (PubChem CID ; 6950374) ; Poly(L-Lactide) (PubChem CID ; not available) ; Poly(D-Lactide) (PubChem CID ; not available) ; Poly(D ; L-lactide) (PubChem CID ; not available) ; Tin(II) 2-ethylhexanoate (PubChem CID ; 9318) ; Aluminum isopropoxide (PubChem CID ; 70700058)
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：107
• 期：Complete
• 页码：3-16
• 全文大小：1532 K
• 卷排序：107

文摘

Polylactides with various molar masses, microstructures and crystallinities are used as degradable and biocompatible polymers suitable for preparation of drug carriers and temporary medical implants. This paper presents state of current knowledge on synthesis of lactic acids, high purity lactide monomers and their polymerization. Syntheses of high molar mass polylactides by polycondensation of lactic acid and by ring-opening polymerization of lactides are described and their advantages and disadvantages are discussed. Mechanisms of lactide polymerization initiated by metal alkoxides are described. There are presented also results of more recent studies of polymerization initiated with the so-called “no metal” organocatalysts; both anionic and cationic. Presented are advantages and limitations of synthesis of PLA by all the major polymerization processes until now. Some properties of PLA and most important methods used for PLA characterization are also described.