Preconditioning of physiological cyclic stretch attenuated HMGB1 expression in pathologically mechanical stretch-activated A549 cells and ventilator-induced lung injury rats through inhibition of IL-6/STAT3/SOCS3
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- 作者：Xiang-Zhi Fang ; Tian-Feng Huang ; Cun-Jin Wang ; Ya-Li Ge ; Shun-Yan Lin ; Yang -Zhang ; Ju Gao ; gaoju_003@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Preconditioning ; IL-6/STAT3 ; SOCS3 ; Lung injury ; Mechanical ventilation
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：66-73
- 全文大小：1464 K
文摘
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Preconditioning of 5% CS suppresses HMGB1 expression in A549 cells following 20% CS.
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Low tidal volume ventilation preconditioning suppresses HMGB1 expression in VILI rats.
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The inhibitory effect was mediated by suppressing IL-6/STAT3/SOCS3.
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Low tidal volume ventilation preconditioning decreases the severity of VILI.