HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer
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- 作者：Bin Hua ; b ; 1 ; Kundong Zhangb ; c ; 1 ; Shaobo Lid ; 1 ; Hao Lib ; c ; Zhaowen Yand ; Li Huanga ; b ; Jianghong Wua ; b ; Xiao Hana ; b ; Weiliang Jianga ; b ; Tunike Mulatibiekea ; b ; Lin Zhengd ; Rong Wana ; b ; Xingpeng Wanga ; b ; richardwangxp@163.com" class="auth_mail" title="E-mail the corresponding author ; Guoyong Hua ; b ; huguoyongsh@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIC1 ; Pancreatic cancer ; IL-6/STAT3 ; Invasion ; Metastasis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：376
- 期：2
- 页码：387-398
- 全文大小：6260 K
文摘
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Expression of HIC1 is silenced in PDAC, which predicts worse patient survival and prognosis.
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HIC1 inhibits pancreatic cancer invasion and metastasis.
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HIC1 impairs STAT3 DNA binding activity and represses STAT3 target genes expression.
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HIC1 and STAT3 interaction is very important to elucidate the mechanism of pancreatic cancer invasion and metastasis.