Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro
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- 作者：Xiaofang Maa ; 1 ; Jiaxiu Dengb ; 1 ; Ning Caoa ; Zhenzhen Guoa ; Yaqiu Zhenga ; Shengnan Genga ; Mingjing Menga ; Haihong Lina ; Yongjian Duanb ; dyj9062@163.com" class="auth_mail" title="E-mail the corresponding author ; Gangjun Dua ; 724200@henu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Urethane ; Carcinogenesis ; Cancer stem cells ; Glycolytic stress
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：240
- 期：1
- 页码：130-139
- 全文大小：5080 K
文摘
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The mouse strains have different susceptibility to lung carcinogenesis.
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Urethane-induced lung carcinogenesis is associated with glycolytic stress.
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Lasting glycolysis removes difference of susceptibility to lung carcinogenesis.
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Glycolytic metabolism is a direct initiator of tumorigenesis.
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10× injection of urethane is a valuable model for studying lung carcinogenesis.