Regulation of lipid disorders by ethanol extracts from Zingiber zerumbet in high-fat diet-induced rats

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• 作者：Chia Ju Chang^a ; ^{7419417@yahoo.com.tw} ; Thing-Fong Tzeng^b ; ^{johnson0425.tzeng@gmail.com} ; Shorong-Shii Liou^c ; ^{ssliou@mail.tajen.edu.tw} ; Yuan-Shiun Chang^a ; ^{2770727@yahoo.com.tw} ; I-Min Liu^c ; ^{iml@mail.tajen.edu.tw}
• 关键词：Acyl-CoA oxidase ; Cytochrome P450 isoform 4A1 ; High-fat diet ; Peroxisome proliferator activated receptor ¦Á ; Zingiber zerumbet
• 刊名：Food Chemistry
• 出版年：2012
• 出版时间：1 May 2012
• 年：2012
• 卷：132
• 期：1
• 页码：460-467
• 全文大小：1098 K

文摘

The aim of this study was to investigate the antihyperlipidaemic effects of the ethanol extract of Zingiber zerumbet (L) Smith (EEZZ). After being fed a high-fat diet (HFD) for 2 weeks, rats were dosed orally with EEZZ (100, 200 or 300 mg/kg) or fenofibrate (100 mg/kg) once daily for 8 weeks. EEZZ (300 mg/kg/day) produced effects similar to fenofibrate in reducing body weight gain, visceral fat-pad weights and plasma lipid levels. EEZZ caused reductions in hepatic triglyceride and cholesterol content, and lowered hepatic lipid droplet accumulation and the size of epididymal adipocytes. HFD-induced reductions in the hepatic proteins of peroxisome proliferator-activated receptor (PPAR) ¦Á, acyl-CoA oxidase (ACO) and cytochrome P450 isoform 4A1 (CYP4A1) were reversed by EEZZ. These results suggest that EEZZ reduced the accumulation of visceral fat and improved hyperlipidaemia in HFD-fed rats by increasing fatty acid oxidation, an effect which is likely to be mediated via up-regulation of hepatic PPAR¦Á.