Interdependent adrenergic receptor regulation of Arc and Zif268 mRNA in cerebral cortex
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- 作者：Norah Essalia ; Jeff Sandersb ; jeff.d.sanders@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arc ; activity regulated cytoskeleton associated protein ; AR ; adrenergic receptor ; IEG ; immediate early gene ; LTP ; long term potentiation ; PBS ; phosphate-buffered saline ; RX821002 ; 2-[2-(2-methoxy-1 ; 4-benzodioxanyl)]imidazoline hydrochloride ; DSP4 ; N-(2-chloroethyl)-n-ethyl-2-bromobenzylamine hydrochloride
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：612
- 期：Complete
- 页码：38-42
- 全文大小：1076 K
文摘
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α2-AR uniquely exert an inhibitory regulation of both Arc and Zif268 compared to α1 and β-AR.
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The α2-AR antagonist, RX821002, increases Arc and Zif268 interdependent with α1 and β-AR.
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A lack of adult IEG response to combined α1 and β-AR blockade contrasts with decreases to n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine hydrochloride (DSP4).