d="p0005">A reliable hepatopancreas protein extraction method was established.
dd><dt class="label">•dt><dd>d="p0010">81.93% of the total hepatopancreas proteins were distributed in the range of pI 4–7.
dd><dt class="label">•dt><dd>d="p0015">37 proteins exhibited significant alterations upon cold stress.
dd><dt class="label">•dt><dd>d="p0020">Cold stress may lead to the decline of innate immunity of the shrimp.
dd><dt class="label">•dt><dd>d="p0025">The anabolism is vigorous in the hepatopancreas under cold stress.
dd>dl>