Effects of chronic lead exposure on learning and reaction time in a visual discrimination task

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• 作者：Morgan ; R.E. ; et. al.
• 关键词：Lead poisoning ; Lead exposure ; Adverse effects ; Reaction time ; Learning ; Associative ability ; Information-processing speed
• 刊名：Neurotoxicology and Teratology
• 出版年：2000
• 出版时间：May - June, 2000
• 年：2000
• 卷：22
• 期：3
• 页码：337-345
• 全文大小：386 K

文摘

Long–Evans rats exposed chronically to lead (Pb) acetate (0, 75, or 300 ppm) were tested as adults on an automated, three-choice visual discrimination task as part of a larger study designed to elucidate the cognitive effects of developmental Pb exposure. Median adult BPb levels for the groups were <5, 20, and 36 μg/dl. The pattern of results suggested a linear effect, with increasing lead dose producing progressively slower learning and an increased incidence of “impaired” individuals. This latter measure proved to be slightly more sensitive than the former, suggesting individual differences in susceptibility to Pb neurotoxicity. Additional analyses revealed that the impairing effect of Pb was seen in both the chance and post-chance learning phases, indicating that the deficit was not limited to (but could include) attentional function. Reaction time on incorrect trials was reduced in the 300-ppm group, whereas no Pb effect was seen for correct trials. The present findings suggest that chronic developmental Pb exposure produces an associative deficit as well as a tendency to respond rapidly, but does not affect information-processing speed. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0892-0362(00)00065-9 Publication Type: Article ISSN: 0892-0362 Cited by:

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2. Garber, M.M.; Heiman, A.S.,""The in vitro effects of Pb acetate on NO production by C6 glial cells""Toxicology in Vitro2002pp. 499-508
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3. Morley, Eric J.; Hirsch, Helmut V.B.; Hollocher, Kurt; Lnenicka, Gregory A.,""Effects of Chronic Lead Exposure on the Neuromuscular Junction in Drosophila Larvae""Neurotoxicology2003pp. 35-41
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4. Hirsch, Helmut V.B.; Mercer, John; Sambaziotis, Hera; Huber, Michael; Stark, Diane T.; Torno-Morley, Tara; Hollocher, Kurt; Ghiradella, Helen; Ruden, Douglas M.,""Behavioral Effects of Chronic Exposure to Low Levels of Lead in Drosophila melanogaster""Neurotoxicology2003pp. 435-442
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5. Widholm, John J.; Seo, Byung-Woun; Strupp, Barbara J.; Seegal, Richard F.; Schantz, Susan L.,""Effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on spatial and visual reversal learning in rats""Neurotoxicology and Teratology2003pp. 459-471
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Footnotes:

1. Present address: Psychology Department, Western Illinois University, Macomb, IL 61455, USA.