Differentiation of human γδ T cells towards distinct memory phenotypes

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• 作者：Eberl ; Matthias ; Engel ; Rosel ; Beck ; Ewald ; Jomaa ; Hassan
• 关键词：γ ; &#948 ; T cells ; Vγ ; 9/V&#948 ; 2 T cells ; IL-21 ; Interleukin-21 ; Cytokines ; Memory ; Phosphoantigen ; (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate ; Isoprenoid biosynthesis
• 刊名：Cellular Immunology
• 出版年：2002
• 出版时间：July - August, 2002
• 年：2002
• 卷：218
• 期：1-2
• 页码：1-6
• 全文大小：149 K

文摘

Vγ9/Vδ2 T cells comprise a small population of peripheral T cells responding towards the low molecular weight antigen, (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate (HMB-PP). HMB-PP-stimulated Vγ9/Vδ2 T cells proliferated, expressed CCL5/RANTES, and upregulated markers like CD16, CD25, CD69, and CD94, in the presence of either IL-15 or IL-21. Vγ9/Vδ2 T cells grown in the presence of IL-15 differentiated into an effector/memory population characterized by production of TNF-α, expression of CD45RO and CCR5, and lack of CD62L, CD81, and CCR7. In contrast, Vγ9/Vδ2 T cells grown with IL-21 differentiated into putative central memory CD45RO⁺ T cells that did not produce TNF-α, IFN-γ, or IL-4, and maintained expression of CD62L, CD81, and CCR7.