Non-peptide antigens activating human Vγ9/Vδ2 T lymphocytes

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• 作者：Poupot ; Mary ; Fournié ; Jean-Jacques
• 关键词：Non-peptide antigens ; Vγ ; 9/V&#948 ; 2 T lymphocytes ; γ ; &#948 ; T cell
• 刊名：Immunology Letters
• 出版年：2004
• 出版时间：September, 2004
• 年：2004
• 卷：95
• 期：2
• 页码：129-138
• 全文大小：530 K

文摘

Various non-peptidic ligands which specifically activate most of circulating human Vγ9/Vδ2 T lymphocytes are now known. Most of these are so-called phosphoantigens and directly trigger the Vγ9/Vδ2 TCR expressing cells, without need for MHC-restricted presentation molecules. Although some potent phosphoantigens currently involved in clinical trials are chemically-synthesized molecules, most of the natural antigens were isolated from microbial cultures. The structures and biosynthesis of phosphoantigens are reviewed here and the possible physiological significance of their recognition by γδ T lymphocytes is discussed.