Glutamate in peripheral organs: Biology and pharmacology

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• 作者：Jie Du^a ; ^b ; Xiao-Hui Li^a ; Yuan-Jian Li^a ; ^{yuan_jianli@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Glutamic acid (PubChem CID ; 611) ; Aspirin (PubChem CID ; 2244) ; (RS)-1-aminoindan-1 ; 5 ; dicarboxylic acid (AIDA) (PubChem CID ; 2071) ; Dizocilpine (MK-801) (PubChem CID ; 9862634) ; 2-amino-5-phosphono-valcrate (APV) (PubChem CID ; 135342) ; 2-amino-7-phosphonoheptanoate (PubChem CID ; 18538056) ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione (CNQX) (PubChem CID ; 3721046) ; Phencyclidine (PCP) (PubChem CID ; 6468) ; Ketamine (PubChem CID ; 3821) ; Dextrorphan (PubChem CID ; 5360697) ; 2 ; 3-dihydroxy-6-nitro-7-sulfamoyl-benzo
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：5 August 2016
• 年：2016
• 卷：784
• 期：Complete
• 页码：42-48
• 全文大小：312 K

文摘

Glutamate is a versatile molecule existing in both the central nervous system and peripheral organs. Previous studies have mainly focussed on the biological effect of glutamate in the brain. Recently, abundant evidence has demonstrated that glutamate also participates in the regulation of physiopathological functions in peripheral tissues, including the lung, kidney, liver, heart, stomach and immune system, where the glutamate/glutamate receptor/glutamate transporter system plays an important role in the pathogenesis of certain diseases, such as myocardial ischaemia/reperfusion injury and acute gastric mucosa injury. All these findings provide new insight into the biology and pharmacology of glutamate and suggest a potential therapeutic role of glutamate in non-neurological diseases.