Expression patterns of the chromosome 21 MicroRNA cluster (miR-99a, miR-125b and let-7c) in chorioamniotic membranes

详细信息    查看全文

• 作者：Bhavi P. Modi^a ; ^{modibp@vcu.edu} ; Sonya Washington^b ; ^{sonya.washington@vcuhealth.org} ; Scott W. Walsh^b ; ^{scott.walsh@vcuhealth.org} ; Colleen Jackson-Cook^a ; ^b ; ^c ; ^{colleen.jackson-cook@vcuhealth.org} ; Kellie J. Archer^d ; ¹ ; ^{archer.43@osu.edu} ; Jerome F. Strauss III^a ; ^b ; ^{jerome.strauss@vcu.health.org}
• 关键词：Hsa-miR-99a ; Hsa-miR-125b ; Hsa-let-7c ; Trisomy-21 ; Amnion ; Choriodecidua
• 刊名：Placenta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：1-9
• 全文大小：1680 K
• 卷排序：49

文摘

Expression of Chromosome 21 miRNAs (miR-99a, miR-125b, let-7c) was investigated. Altered expression of these miRNAs in trisomy 21 amniocytes was established. Tissue/location specific expression patterns in fetal membranes were observed. Roles in fetal membrane abnormalities associated with trisomy 21 are suggested.