Patients with Small Abdominal Aortic Aneurysm are at Significant Risk of Cardiovascular Events and this Risk is not Addressed Sufficiently

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• 作者：M.F. Bath^a ; ^c ; ^{michael.bath@doctors.org.uk} ; A. Saratzis^a ; ^c ; ^{as875@le.ac.uk} ; M. Saedon^b ; D. Sidloff^a ; R. Sayers^a ; M.J. Bown^a ; UKAGS investigatorsR. Pathak ; M. Brooks ; P. Hayes ; C. Imray ; J. Quarmby ; S. Choksy ; J. Earnshaw ; C.P. Shearman ; E. Grocott ; T. Rix ; I. Chetter ; W. Tennant ; G. Libertiny ; T. Sykes ; M. Dayer ; L. Pike ; A. Pherwani ; C. Nice ; N. Browning ; C. McCollum ; S. Yusuf ; M. Gannon ; J. Barwell ; S. Baker ; S.R. Vallabhaneni ; A. Davies
• 关键词：Abdominal aortic aneurysm ; Cardiovascular ; Risk reduction
• 刊名：European Journal of Vascular and Endovascular Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：53
• 期：2
• 页码：255-260
• 全文大小：134 K
• 卷排序：53

文摘

Patients with abdominal aortic aneurysm (AAA) are at significant risk of cardiovascular (CV) events. Recent implementation of AAA-screening means thousands of patients are now diagnosed with small-AAA; however, CV risk factors are not always addressed. This study aimed at assessing and quantifying the CV characteristics of patients with small AAA following the introduction of screening programmes.MethodsCV profiles of 384 men with a small AAA (<55 mm diameter) were assessed through the United Kingdom Aneurysm Growth Study (UKAGS), a nationwide prospective cohort study of men with small AAA. A prospective local cohort of an additional 142 patients with small AAA with available blood pressure (BP) and lipid profiles was also included and followed-up for 1 year.ResultsIn the UKAGS population, 54% were current and 30% ex-smokers; 58% were hypertensive and 54% hypercholesterolaemic. In the local group, 54% were current and 40% were ex-smokers, and 94% were hypertensive. Patients were not more likely to receive CV medication after entering AAA surveillance in either group. All local patients were clustered “high-risk” for future CV events based on the Framingham score (mean 21.8%, 95% CI 20.0–23.6), JBS-2 (16.3%, 14.7–17.9) and ASSIGN (25.2%, 22.7–27.7). No change was seen in systolic BP levels between baseline and 1 year (140.9 mmHg vs. 142.5 mmHg, p=.435). A rise was seen in cholesterol (4.0 mmol–4.2 mmol, p<.0001) values at 1 year.ConclusionsThis study suggests that patients with small AAA are at significant risk for developing CV events and this is not currently addressed, which is evident by the “high-risk” CV risk profiles of these patients despite being in AAA surveillance. Design and implementation of a CV risk reduction programme tailored for this population is necessary.