Dysferlin plays critical roles in plasma membrane repair, vesicle trafficking and membrane remodeling.

Mutations in the dysferlin gene cause are a group of muscular dystrophy known as dysferlinopathies.

Dysferlinopathies are manifested with an inflammatory response that further contributes to the disease progression.

The m>de novom> expression of connexin hemichannels may contribute to the inflammatory process associated to dysferlinopathy.

The persistent expression of connexin based hemichannels in the sarcolemma could constitute an interesting therapeutical target.