Telomerase Is Essential for Zebrafish Heart Regeneration
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- 作者：Dorota Bednarek1 ; Juan Manuel Gonzá ; lez-Rosa2 ; 6 ; 7 ; Gabriela Guzmá ; n-Martí ; nez3 ; Ó ; scar Gutié ; rrez-Gutié ; rrez1 ; Tania Aguado1 ; Carlota Sá ; nchez-Ferrer1 ; Inê ; s Joã ; o Marques2 ; Marí ; a Galardi-Castilla2 ; Irene de Diego1 ; Manuel José ; Gó ; mez4 ; Alfonso Corté ; s5 ; Agustí ; n Zapata5 ; Luis Jesú ; s Jimé ; nez-Borreguero3 ; Nadia Mercader2 ; 8 ; nmercader@cnic.es" class="auth_mail" title="E-mail the corresponding author ; Ignacio Flores1 ; iflores@cnic.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：12
- 期：10
- 页码：1691-1703
- 全文大小：6496 K
文摘
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Telomerase hyperactivation is an early event during zebrafish heart regeneration
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Telomerase loss of function impairs cardiac regeneration
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The proliferative response of cardiomyocytes is inhibited in tert−/− zebrafish
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Telomerase protects cardiac cells from DNA damage and limits cellular senescence