The Diverse Family of Arp2/3 Complexes

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• 作者：Javier Pizarro-Cerd&aacute ; ¹ ; ² ; ³ ; ^{javier.pizarro-cerda@pasteur.fr} ; Dror Shlomo Chorev⁴ ; ⁵ ; Benjamin Geiger⁴ ; Pascale Cossart¹ ; ² ; ³ ; ^{pascale.cossart@pasteur.fr}
• 关键词：Arp2/3 ; actin polymerization ; focal adhesions ; Listeria monocytogenes ; vaccinia virus
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：93-100
• 全文大小：1277 K
• 卷排序：27

文摘

The Arp2/3 complex has so far been considered to be a single seven-subunit protein complex required for actin nucleation and actin filament polymerization in diverse critical cellular functions including phagocytosis, vesicular trafficking and lamellipodia extension. The Arp2/3 complex is also exploited by bacterial pathogens and viruses during cellular infectious processes. Recent studies suggest that some subunits of the complex are dispensable in specific cellular contexts, pointing to the existence of alternative ‘hybrid Arp2/3 complexes’ containing other components such as vinculin or α-actinin, as well as different isoforms or phosphorylation variants of canonical Arp2/3 subunits. Therefore, this diversity should be now considered when assigning specific Arp2/3 assemblies to different actin-dependent cellular processes.