Visible light-induced cytotoxicity of Ru,Os-polyazine complexes towards rat malignant glioma
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- 作者：Jie Zhua ; zjie12@vt.edu" class="auth_mail" title="E-mail the corresponding author ; Anthony Dominijannib ; José ; Á ; . Rodrí ; guez-Corralesa ; Reece Prussinb ; Zongmin Zhaoc ; Tinghui Lia ; John L. Robertsonb ; Karen J. Brewera ; &Dagger ;
- 关键词：Photodynamic therapy ; Ruthenium complexes ; Osmium complexes ; DNA BSA ; Malignant glioma
- 刊名：Inorganica Chimica Acta
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：454
- 期：Complete
- 页码：155-161
- 全文大小：1154 K
文摘
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Two complexes show oxygen-mediated DNA and BSA photocleavage.
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Both compounds show approximately five-fold higher cytotoxicity than cisplatin.
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Compound Font">2 shows promising photocytotoxicity in F98 under red light irradiation.