Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
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- 作者：Jorge Ivá ; n Castillo-Quan1 ; 2 ; 3 ; Li Li1 ; 3 ; Kerri J. Kinghorn1 ; 3 ; Dobril K. Ivanov4 ; Luke S. Tain2 ; Cathy Slack1 ; 2 ; Fiona Kerr1 ; Tobias Nespital2 ; Janet Thornton4 ; John Hardy3 ; Ivana Bjedov1 ; 5 ; Linda Partridge1 ; 2 ; l.partridge@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：GSK-3 ; NRF-2 ; aging ; xenobiotic stress ; Keap1 ; dietary restriction ; triglycerides
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 April 2016
- 年：2016
- 卷：15
- 期：3
- 页码：638-650
- 全文大小：2429 K
文摘
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Lithium extends Drosophila lifespan independent of sex and genetic background
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Lithium reduces triglycerides and confers stress-resistance
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Genetic or pharmacological inhibition of GSK-3 activates NRF-2
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NRF-2 activation is required for the longevity effects of lithium