Low-dimensional compounds containing bioactive ligands. Part VI: Synthesis, structures, in vitro DNA binding, antimicrobial and anticancer properties of first row transition metal complexes with 5-chloro-quinolin-8-ol
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- 作者：Ivan Potočňá ; ka ; ivan.potocnak@upjs.sk" class="auth_mail" title="E-mail the corresponding author ; Peter Vraneca ; Veronika Farkasová ; a ; Danica Sabolová ; b ; Michaela Vata&scaron ; činová ; b ; Jú ; lia Kudlá ; čová ; b ; Ivana D. Radojevićc ; Ljiljana R. Čomićc ; Bojana Simovic Markovicd ; Vladislav Volarevicd ; Nebojsa Arsenijevicd ; Srećko R. Trifunoviće
- 关键词：5-Chloro-quinolin-8-ol complexes ; Cytotoxicity ; Antimicrobial activity ; DNA-binding properties ; Topoisomerase I inhibition
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：67-77
- 全文大小：1414 K
文摘
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Eight 3d complexes with 5-chloro-quinolin-8-ol (ClQ) are characterized.
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Complexes interact with DNA by intercalative binding mode.
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Complexes target topoisomerase I as mildly effective topoisomerase inhibitors.
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[Fe(ClQ)3] complex is highly active against human breast MDA-MB cancer cell line.
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[Fe(ClQ)3] complex is not cytotoxic against control mesenchymal stem cells.