Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation
Dysbiosis is accompanied by gut-liver axis alteration in HFD-induced NAFLD. Quercetin prevents dysbiosis-induced TLR4-mediated inflammation and lipotoxicity. Quercetin counteracts inflammasome and reticulum stress pathway activation. Modulatory effects displayed by quercetin counteract lipid metabolism deregulation. Quercetin improves NAFLD via an integrative response including its prebiotic effect.