The ^95ΔG mutation in the 5′untranslated region of the norA gene increases efflux activity in Staphylococcus epidermidis isolates

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• 作者：Elizabeth Garcí ; a-Gó ; mez^a ; Marcos E. Jaso-Vera^a ; Marco A. Ju&aacute ; rez-Verdayes^a ; Marí ; a D. Alc&aacute ; ntar-Curiel^b ; Juan C. Zenteno^c ; Gabriel Betanzos-Cabrera^d ; Humberto Peralta^e ; Sandra Rodrí ; guez-Martí ; nez^f ; Mario E. Cancino-Dí ; az^f ; Janet Jan-Roblero^a ; Juan C. Cancino-Diaz^a ; ^{jccancinodiaz@hotmail.com}
• 关键词：NorA ; Staphylococcus epidermidis ; Efflux ; 5&prime ; UTR ; Mutation ; Shine-Dalgarno
• 刊名：Microbial Pathogenesis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：139-148
• 全文大小：1402 K
• 卷排序：103

文摘

The 5′UTR effect of norA gene over the efflux was studied in S. epidermidis. Isolates had a high efflux activity (HEA) phenotypic for ethidium bromide (EtBr). Isolates with HEA had the 5′UTR 95ΔG mutation and high levels of norA expression. The 95ΔG mutation produces changes in the Shine-Dalgarno region. The 5′UTR 95ΔG mutation of norA gene is involved in the EtBr efflux.