Antineuronal Nuclear Autoantibody Type 1/Anti-Hu-Associated Opsoclonus Myoclonus and Epilepsia Partialis Continua: Case Report and Literature Review

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• 作者：Michael Sweeney ; MD^a ; ^{michael.sweeney.1@louisville.edu} ; Matthew Sweney ; MD^b ; M. Mateo Paz Sold&aacute ; n ; MD ; PhD^a ; Stacey L. Clardy ; MD ; PhD^a
• 关键词：opsoclonus-myoclonus ; epilepsia partialis continua ; antineuronal nuclear antibody ; type 1 (ANNA-1) ; anti-Hu ; neuroblastoma
• 刊名：Pediatric Neurology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：65
• 期：Complete
• 页码：86-89
• 全文大小：339 K
• 卷排序：65

文摘

Opsoclonus-myoclonus syndrome is a rare clinical condition that has been associated with neuroblastoma. There are few reported examples of ANNA-1/anti-Hu antibodies in children with neuroblastoma and opsoclonus-myoclonus, all in children aged less than three years of age.MethodsWe describe the new onset of focal seizures without alteration of consciousness and opsoclonus-myoclonus in an 11-year-old girl with ANNA-1/anti-Hu positivity and a paraspinal ganglioneuroblastoma. A systematic review of the literature of children with ANNA-1/anti-Hu positivity and malignancy was also performed.ResultsFourteen patients were identified, eight of whom had opsoclonus-myoclonus. Although epilepsia partialis continua has been described in association with several neuronal autoantibodies, association with ANNA-1/anti-Hu has not been reported.ConclusionsWe describe epilepsia partialis continua in a child with ANNA-1/anti-Hu antibodies and neuroblastoma. Testing for antineuronal antibodies should be considered in children presenting with either opsoclonus-myoclonus or epilepsia partialis continua.