Anti-inflammatory effects of the butanolic fraction of Byrsonima verbascifolia leaves: Mechanisms involving inhibition of tumor necrosis factor alpha, prostaglandin E2 production and migration of polymorphonuclear leucocyte in vivo experimentation
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- 作者：Aline Aparecida Saldanhaa ; Joã ; o Má ; ximo de Siqueirab ; Ana Hortê ; ncia Fonsê ; ca Castroc ; Rosy Iara Maciel de Azambuja Ribeirod ; Flá ; vio Martins de Oliveirae ; Dé ; bora de Oliveira Lopese ; Flá ; via Carmo Horta Pintof ; Denise Brentan Silvag ; h ; Adriana Cristina Soaresa ; adrianasouza@ufsj.edu.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Byrsonima verbascifolia ; Paw edema ; Pleurisy ; Anti-inflammatory activity ; Cytokines ; Condensed tannins
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：123-131
- 全文大小：930 K
文摘
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Tannins, phenolic acids and flavonoids were detected in the BvBF by LC-DAD–MS/MS.
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Butanolic fraction of B. verbascifolia leaves has in vivo anti-inflammatory effect.
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The BvBF inhibited paw edema and polymorphonuclear leucocyte migration in vivo.
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The BvBF decreased tumor necrosis factor alpha and prostaglandin E2 local levels.