Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane
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- 作者：Olga Lenčová ; -Popelová ; a ; lencovao@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Eduard Jirkovský ; a ; jirkovskye@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Hana Jansová ; b ; jansovah@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Anna Jirkovská ; -Vá ; vrová ; b ; jirkovan@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Lucie Vostatková ; -Tichotová ; b ; lucie.tichotova@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yvona Mazurová ; d ; mazurova@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Michaela Adamcová ; e ; adamcova@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Jaroslav Chlá ; deka ; chladekj@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Milo&scaron ; Hrochc ; hrochm@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Zuzana Pokorná ; a ; pokornzu@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Vladimí ; r Ger&scaron ; la ; 1 ; gersl@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Tomá ; &scaron ; &Scaron ; imůnekb ; tomas.simunek@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Martin &Scaron ; těrbaa ; sterbam@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anthracyclines ; Cardiotoxicity ; Cardioprotection ; Dexrazoxane ; Inorganic nitrate and nitrite
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：92-103
- 全文大小：2516 K
文摘
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Nitrate/nitrite shows only limited efficacy against chronic ANT cardiotoxicity.
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The result contrasts with previous findings in I/R injury and acute ANT cardiotoxicity.
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Several toxicity pathways (e.g., mitochondrial) were targeted by nitrite though.
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All of ANT-induced alterations were prevented by DEX suggesting an up-stream target.
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Different efficacy of both strategies may be related to ability to address TOP2b.