Ceramides with a pentadecasphingosine chain and short acyls have strong permeabilization effects on skin and model lipid membranes
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- 作者：Barbora &Scaron ; kolová ; Barbora Janů&scaron ; ová ; Kateřina Vá ; vrová ; ; Katerina.Vavrova@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATR ; attenuated total reflectance ; Cer ; ceramide(s) ; Chol ; cholesterol ; CholS ; cholesterol sulfate ; DFFA ; perdeuterated fatty acid(s) ; FFA ; free fatty acid(s) ; FTIR ; Fourier-transform infrared spectroscopy ; IND ; indomethacin ; SAXD ; small-angle X-ray diffraction ; SC ; stratum corneum ; TH ; theophylline ; WAXD ; wide-angle X-ray diffraction
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1858
- 期：2
- 页码：220-232
- 全文大小：1943 K
文摘
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Ceramides with shortened sphingosine and acyl chains synthesized
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Bell-shaped chain length–permeability relationships with maxima at 15C sphingosine
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Ceramides with 15C-sphingosine: 15 times higher skin permeability
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Ceramides with 15C-sphingosine: 79 times higher membrane permeability
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IR spectroscopy and X-ray diffraction: altered lamellar organization