Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications
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- 作者：Kateřina Hru&scaron ; ková ; Eli&scaron ; ka Potůčková ; Tereza Hergeselová ; Lucie Liptá ; ková ; Pavlí ; na Ha&scaron ; ková ; Panagiotis Mingas ; Petra Kovaří ; ková ; Tomá ; &scaron ; &Scaron ; imůnek ; Tomas.Simunek@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Kateřina Vá ; vrová ; ; Katerina.Vavrova@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Iron chelator ; Hydrazone ; Oxidative injury ; Anticancer ; Structure-activity relationships
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：14 September 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：97-110
- 全文大小：1711 K
文摘
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New structure-activity relationships in aroylhydrazone iron chelators.
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Naphthyl and biphenyl compounds showed selective antiproliferative activities.
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Pyridazine-based hydrazone protected cardiomyoblasts against oxidative stress.
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Low toxicity and good plasma stability in the most active compounds.